Mechanistically, a long noncoding RNA activated by TGF-β (lncRNA-ATB) that is upregulated in HCC and is able to induce the epithelial–mesenchymal transition binds to the IL-11 mRNA and triggers STAT3 signaling through the autocrine induction of IL-11 production [89]. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.