Magini et al. (2016) demonstrated immunization of mice with self-amplifying mRNA expressing conserved internal influenza NP and M1 antigens, delivered individually or in conjugation with lipid nanoparticles (LNanoPs), was able to induce strong polyfunctional CD4 T cells as well as central and effector memory CD4 and CD8 T cells. The gene discussed is CD8A; the disease is influenza.