There are a lot of attempts to use less invasive methods, like serum samples, or non-invasive methods, like urine samples, to make a diagnosis and monitor MGN patients immediately following the detection of anti-phospholipase A2 receptor (PLA2R) and anti-thrombospondin domain containing 7A (THSD7A) in the serum of primary MGN patients. This evidence concerns the gene PLA2R1 and idiopathic membranous glomerulonephritis.