Vehicle control, GW3965, 26-OHC (the most abundant scOHC in breast tumour tissue [7]) or 24,25-EC (the scOHC that elicited the greatest fold induction in reporter cells (Figure 1b)) were added to MDA-MB-468 or MCF7 cells for 4 or 16 h and changes to ABCA1 and APOE expression determined. The gene discussed is APOE; the disease is breast neoplasm.