ESR1 and neoplasm: We repeated these measurements in vitro and found the cell line models recapitulated these features of the primary tumours; MDA-MB-468 expressed significantly more LXRA but not LXRB (Figure 4c), and significantly less NCOR1, NCOR2/SMRT and LCOR transcript than the ER-positive cell line MCF7 (two-tailed student’s t-test: p < 0.0001 for all corepressors (Figure 4d)).