APOE and neoplasm: Then, we assessed correlation of expression of each of these LXRA bound gene targets with NR1H3/LXRA and NR1H2/LXRB expression in publicly available RNA-Seq datasets from TCGA, as previously for ABCA1 and APOE. In ER-negative tumours NR1H3/LXRA significantly correlated with 48/135 genes (Figure 3a), compared to 8/135 in ER-positive tumours (Figure 3b).