NCOR2 and cancer: In the absence of agonist, LXRA but not LXRB, is primarily repressed by corepressors NCOR1 and NCOR2/SMRT [12] and previous reports demonstrate elevated corepressor expression helps prostate [9,10] and bladder [11] cancer cells to evade anti-proliferative actions of NRs through compromising the ligand response.