NR4A1 and obesity due to melanocortin 4 receptor deficiency: LDL-C, Obesity, Waist-Hip-Ratio and Waist Circumference are associated with incidence and survival of BCa [54,55] and clinically recommended diets/lifestyle changes that lower LDL-C (e.g., high fish-oil and carotenoid intake, the Mediterranean Diet, reduced animal calorie intake), protect against BCa and relapse, particularly in the hormone receptor negative setting [41,53,56,57].