LTBP1 and neoplasm: For example, both MDV1-miR-M4-5P and gga-miR-155 target six tumor-associated cellular genes to effectively promote tumorigenesis [29], and MDV1-miR-M4-5p activates oncogene c-Myc by targeting latent transforming growth factor beta binding protein 1 (LTBP1) and inhibiting transforming growth factor beta (TGF-β) signaling pathway, thereby promoting MDV-induced tumorigenesis [30].