Similarly, improvements in the intracellular glutathione pool and in the activity of catalase and SOD enzymes by pretreatment with OA have been reported in PC12 cells, a cell line derived from a pheochromocytoma of rat adrenal medulla, exposed to H2O2 and 1-methyl-4- phenylpyridinium [62]. The gene discussed is SOD1; the disease is pheochromocytoma.