VEGFA and rheumatoid arthritis: In their study with RA patients, concerning non-differentiated arthritis, Berckmans et al. found incubation of MPs obtained from synovial fluid in the presence of FLS obtained by the biopsy of the synovial membrane to result in an increase in production and release by synoviocytes of IL-6, IL-8, monocyte chemoattractant protein 1 (MPC-1), RANTES (regulation on activation normal T-cells expressed and secreted) chemokine, and vascular endothelium growth factor (VEGF) [63].