These two scoring systems are rather different, given that the former considers only the percentage of PD-L1-positive neoplastic cells, while the latter combines all PD-L1-positive cells (i.e., tumor cells, lymphocytes, and macrophages) into the following formula.CPS=NumberofPDL1positivecellsTotalnumberofviabletumorcells × 100. The gene discussed is CD274; the disease is neoplasm.