GHRL and Anorexia: Conversely, the pro-opiomelanocortin/cocaine and amphetamine regulated transcript neurons promote anorexia (anorexigenic), are inhibited by ghrelin, stimulated by white adipose tissue (WAT) cytokines (e.g., leptin, adiponectin), and activate the sympathetic nervous system to increase REE via browning of AT and the uncoupling protein (UCP) [1,51,52].