Reactive oxygen species produced by catabolic cancer cells and the downregulation of the Krebs cycle enzyme isocitrate dehydrogenase 3α (IDH-3α) upregulates HIF-1α and NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2), which in turn inhibits OXPHOS and promotes CAF glycolysis [33] (Figure 2, 4). This evidence concerns the gene COXFA4L2 and cancer.