CLDN1 and cancer: We did note several instances of different family members expressed across both sets (e.g., Sod3, Krt6b/78, Tmprss4/11bnl and Cldn1/23/b8 in epithelia, and Sod1/2, Krt7/19, Tmprss13 and Cldn7 in cancer), suggesting that loss of Grhl-mediated transcription may lead to similar biological consequences, albeit mediated via different (possibly secondary, or indirect) target pathways.