In addition, a recent study on human DIPG patients to assess spatial and temporal driver mutations pointed to H3K27M as the initial oncogenic event in DIPG, which needed a partner driver, such as ACVR1 (or TP53, PPMID, or PIK3R1) to induce oncogenesis [156]. Here, PIK3R1 is linked to diffuse intrinsic pontine glioma.