WNK2 and melanoma: It indicated that the mechanism by which CMSP affects the viability of melanoma B16–F1 cells is the induction of B16-F1 melanoma cells differentiation via the Ras homolog gene family, member A- mitogen-activated protein kinase- Mitogen-activated protein kinase- Mitogen-activated protein kinase (RhoA–MAPK)signaling pathway.