The key targets included MAPK3, MAPK1, PIK3CA, AKT1, MAPK14, MAPK8, PRKCA, EGFR, and JAK1 (degree ≥ 10) and the key pathways included the neuroactive ligand–receptor interaction, influenza A, pathways in cancer, and Rap1 signaling pathway. The gene discussed is MAPK1; the disease is cancer.