TNF and neoplasm: Other angiogenic proteins frequently found in tumor stroma include the heparin-binding protein CYR61 that promotes migration and adhesion of endothelial cells inducing neovascularization [68], MCP-1 (monocyte chemotactic protein 1) [69], CEA related cell adhesion molecule-1 [70], tumor necrosis factor α [71], brain-derived neurotrophic factor [72], platelet-derived endothelial cell growth factor [73], BMP2 (bone morphogenetic protein 2) [74] are among other angiogenic proteins frequently found in tumor stroma.