While it is true that PI3K signaling cascade is implicated in numerous physiological processes such as cell survival, proliferation, protein synthesis, and cellular metabolism, it has also been demonstrated that several types of cancers present aberrant expression of PI3K tumor suppressor PTEN, Akt, mTORC, and several other molecules within the PI3K/mTORC pathways. This evidence concerns the gene AKT1 and cancer.