One of these key regulators, responsible for controlling the processes involved in cells metabolism, survival, and proliferation, is the intracellular phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin (PI3K/Akt/mTOR) signaling pathway, that has been discovered to be dysregulated in several types of cancer [1]. The gene discussed is AKT1; the disease is cancer.