Regarding the downregulated mediators identified in CIA plasma, Vascular endothelial growth factor (VEGF), Fractalkine, IL-18, C-X-C motif chemokine 5 (CXCL5, LIX), and Leptin, only Fractalkine and Leptin levels were statistically significantly lower in the CIA+FD group, relative to control. This evidence concerns the gene LEP and Fabry disease.