Furthermore, miR221/222 were demonstrated as the main regulators of BC cell proliferation and invasion by targeting the signal transducer and activator of transcription 5A (STAT5A), disintegrin and metalloproteinase domain 17 (ADAM17) and integrin β4 (ITGB4) genes; ITGB4 encodes an adhesion molecule that interacts with laminin receptors. The gene discussed is STAT5A; the disease is breast cancer.