In further study described tumor protein p53 binding protein 1 (TP53BP1, 53BP1) as a novel negative regulator of EMT through the miR-200b/429-mediated down-regulation of ZEB1. Although 53BP1 expression positively correlated with both miR-200b and miR-429 expression and negatively correlated with ZEB1 gene expression in 18 BC samples, in vitro experiments failed to show direct interaction between 53BP1 and these two miRNAs [155]. The gene discussed is TP53BP1; the disease is breast cancer.