SNAI2 and breast cancer: In addition, several proteins associated with BC invasiveness are capable of regulating some of the abovementioned miRNAs; here, TWIST1 acted as an inducer or repressor of the miR-10b and miR-200 cluster, SNAIL2 stimulated miR-221 up-regulation, and the proteolytically active ADAM8 activated miR-720 expression [81,119,158,165].