Furthermore, miR221/222 were demonstrated as the main regulators of BC cell proliferation and invasion by targeting the signal transducer and activator of transcription 5A (STAT5A), disintegrin and metalloproteinase domain 17 (ADAM17) and integrin β4 (ITGB4) genes; ITGB4 encodes an adhesion molecule that interacts with laminin receptors. Here, ITGB4 is linked to breast cancer.