For the sub-group of children affected by metastatic HB, the AFP level was identified as the most significant prognostic factor: an AFP level of 100–1000 ng/mL at diagnosis was related to a 5-year EFS of 18%, while children with AFP > 1000 ng/mL had a 5-year EFS of 47% (p < 0.0001) [2]. Here, AFP is linked to hemoglobin measurement.