There are more than 13 genes associated with CMD, and the primary disease subtypes are caused by laminin alpha-2 (merosin) deficiency (MDC type 1A, MDC1A) or partial merosin deficiency (MDC1B), fukutin-related proteinopathy (MDC1C), or acetylglucosaminyltransferase-like protein (LARGE)-related CMD (MCD1D) [51]. Here, LAMA2 is linked to hyperinsulinemic hypoglycemia, familial, 4.