DES and neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan: The most common subtypes are LGMD1A (myotilinopathy), LGMD1B (laminopathy), LGMD1C (caveolinopathy), LGMD1E and LGMD2R (desminopathies), LGMD2A (calpainopathy), LGMD2B (dysferlinopathy), LGMD2C, 2D, 2E, and 2F (the sarcoglycanopathies), LGMD2G (telethoninopathy), LGMD2I, 2K, 2M, 2N, 2O, 2P, 2T, and 2U (the dystroglycanopathies), LGMD2J (titinopathy), and LGMD2L.