We did gain-of- and loss-of-functional tests and confirmed that depletion of HOXA9 enhances the proliferation and decreases the apoptosis of cSCC cells as shown by repressed cleaved CASPASE3 generation and apoptotic cells (Figure 1a–c), while overexpression of HOXA9 indeed plays tumor-suppressive roles by inhibiting the proliferation and promoting apoptosis in cSCC cells (Figure 1d–f), which is consistent with the previous report [15]. The gene discussed is HOXA9; the disease is neoplasm.