In contrast to the abovementioned experimental autoimmune encephalomyelitis model in which AHR ligation enhances IL-17 and IL-22 production, Ahr-deficiency augments Th17 cell differentiation in the intestinal tract where large amounts of dietary- and microbiota-derived AHR ligands are present [80]. The gene discussed is IL22; the disease is experimental autoimmune encephalomyelitis.