SLFN11 and neoplasm: Using an extensive correlation analyses involving 1190 cell lines and 56 drugs belonging to 5 different chemotherapeutic classes, we identified SLFN11 as the transcript most strongly predictive of response to alkylating agents, anti-metabolites, anti-tumor antibiotics, and topoisomerase inhibitors, all of which induce DNA damage, but not to microtubule inhibitors.