Comparisons to random networks of same complexity (degree-preserving network permutations) in combination with further filtering revealed ten candidates from DU145 (ADAMTS9, AKR1B10, CXXC5, FST, FOXL1, GRPR, ITGA2, SOX17, STARD4, VGF) and four from LNCaP (FHL5, LYPLAL1, PAK7, TDRD6) that were able to distinguish irradiated prostate cancer patients from TCGA into early and late relapse groups. The gene discussed is AKR1B10; the disease is Familial prostate cancer.