Commonly underexpressed genes in radioresistant DU145 and LNCaP included e.g. known tumor suppressors (e.g. BCL10, EPB41L4A, SPRED1, SERPINB5) and commonly overexpressed genes included e.g. SEMA4A involved in cell-cell signaling and migration, NROB1 associated with stem cell pluripotency, and genes involved in cytokine signaling (e.g. IL19, IL3RA) [36]. This evidence concerns the gene SPRED1 and neoplasm.