Comparisons to random networks of same complexity (degree-preserving network permutations) in combination with further filtering revealed ten candidates from DU145 (ADAMTS9, AKR1B10, CXXC5, FST, FOXL1, GRPR, ITGA2, SOX17, STARD4, VGF) and four from LNCaP (FHL5, LYPLAL1, PAK7, TDRD6) that were able to distinguish irradiated prostate cancer patients from TCGA into early and late relapse groups. This evidence concerns the gene PAK5 and Familial prostate cancer.