Our findings are in line with previous reports, which indicated associations among CSF AD biomarkers (t-tau, phosphorylated –tau; Aβ-42 and t-tau/ Aβ-42 ratio) and decreased FA or increased MD in specific ROI’s bundles, such as the cingulum [92], the parahippocampal gyrus, the precuneus and the inferior temporal regions [93]. The gene discussed is MAPT; the disease is Alzheimer disease.