FUS and amyotrophic lateral sclerosis: FUS exerts its function as a DNA‐/RNA‐binding protein primarily in the nucleus and is centrally implicated in splicing regulation, stress granule formation, and DNA repair.11, 12 We and others recently reported on drastically increased DNA damage in various cell types with FUS‐NLS mutations, which was shown to be associated with neuronal cell death.13, 14, 15 It is, however, not known if other cells in FUS‐ALS patients are also affected by accumulated DNA damage leading to genomic instability, which is the basis for the multistep process of cancer development.