FUS and amyotrophic lateral sclerosis: Mutations in more than 38 genes were identified to be implicated in the pathological MN degeneration.2 In 1% of sporadic and up to 5% of familial ALS cases, mutations in Fused in Sarcoma (FUS) were found to be causative,3 primarily located in the PY‐nuclear localization sequence (NLS) of the protein and are often associated with a more severe course compared to patients with C9ORF72, TBK1, TARDBP, or SOD1 mutations.