The typical predilection sites of NBD are brainstem and basal ganglia.1 Non‐parenchymal lesions such as cerebral venous thrombosis and acute meningeal syndrome have been reported as findings of non‐parenchymal NBD.1 White matter lesions without site predilection have been reported as one of the findings of NSD.2 Our study suggests that patients with CNS inflammation and white matter lesions without site predilection or non‐parenchymal lesions have a potential auto‐inflammatory background associated with MEFV gene mutations. Here, MEFV is linked to inflammation.