The NLRP3 inflammasome is the most abundant inflammasome in the CNS and is a key contributor to neuroinflammation across a broad spectrum of nervous system disorders.14 It has been hypothesized that the pyrin protein suppresses the activation of procaspase‐1 and therefore interferes with NLRP3 inflammasome activation.15 Considering that pyrin is encoded by the human MEFV gene,16 our results suggest that CNS inflammation and symptoms related to NBD and NSD might be associated with dysfunction of pyrin‐dependent regulation of the inflammasome. The gene discussed is NLRP3; the disease is nervous system disorder.