For example, biological targets identified in human liver cancer cells using a library of tagged C75 analogs revealed previously unknown putative C75 targets, including protein disulfide-isomerase A3 (PDIA3), transferrin receptor (TRFC), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Cheng et al., 2014). Here, PDIA3 is linked to liver cancer.