VHL and chromophobe renal cell carcinoma: Previous studies using NGS have revealed the occurrence of evolutionary convergent phenotypic events, despite divergent genotypic alterations, in genes related to cRCC pathogenesis, including distinct mutations in genes involved in the PI3K-AKT-mTOR pathway, chromatin remodeling, and the VHL-HIF pathway (Voss et al., 2014; Riazalhosseini and Lathrop, 2016).