BAP1 and renal cell carcinoma: Figure 3A depicts all loss-of-function (LOF), gain-of-function (GOF), and unknown variants detected in RCC cohort. As shown in this figure, patient RDX-1 harbored a variant with unknown significance (p.Y173C) in the BAP1 gene. This variant has been predicated to be an inactivating alteration (Klebe et al., 2015). However, because it has not been functionally characterized, we are reporting it as a variant of unknown significance. It has been reported that the BAP1 gene is mutated in 12% of cRCC patients (Riazalhosseini and Lathrop, 2016).