Symptoms associated with CTD
At least one of: (1) Raynaud's phenomenon; (2) arthralgias/multiple joint swelling; (3) photosensitivity; (4) unintentional weight loss; (5) morning stiffness; (6) dry mouth or dry eyes (Sicca features); (7) dysphagia; (8) recurrent unexplained fever; (9) gastro-esophageal reflux; (10) skin changes (rash); (11) oral ulceration; (12) nonandrogenic alopecia; (13) proximal muscle weakness; Positive autoimmune serologyPositive finding of at least one of:(1) ANA; (2) RF; (3) anti-Scl70 antibody; (4) SS-A or SS-B; (5) Jo-1 antibody; (6) ESR (2 times normal), CRP. This evidence concerns the gene CRP and gastroesophageal reflux disease.