SP1 and Hepatic fibrosis: An array of sequence-specific transcription factors involved in liver fibrosis, including SMAD (Morita et al., 2007), SRF (Small et al., 2010), YAP/TAZ (Piersma et al., 2015), and Sp1 (Luchsinger et al., 2011), have been reported to interact with MRTF-A to program the fibrogenic response.