In consistence with their restricted expression and function during capacitation, mutations in some genes encoding for some of the above ionic transporters (CatSPER1, CatSPER2, SLC26A3, and SLC26A8) were associated with male infertility due to asthenozoospermia, a pathology defined by reduced or absence of sperm motility (Hildebrand et al., 2010; Ray et al., 2017; Wedenoja et al., 2017). This evidence concerns the gene SLC26A8 and Reduced sperm motility.