SLC26A3, also called Down Regulated in Adenoma (DRA), was cloned in 1993 by Schweinfest et al. (1993) and later showed to encode for an intestinal anion transport molecule (Silberg et al., 1995) whose mutations lead to congenital Chloride Loosing Diarrhea (CLD; [MIM 214700]) (Hoglund et al., 1996), an autosomal recessive disorder due to defective intestinal electrolyte absorption (Kere et al., 1999; Wedenoja et al., 2011). This evidence concerns the gene SLC26A3 and adenoma.