The expression of some miRNAs was shown to influence HCC development via dysregulation of a number of cancer-associated molecular pathways, including TGF-β, p53, WNT/β-catenin, P13K/AKT/mTOR, RAS/MAPS, MET, and MYC (Negrini et al., 2011). The gene discussed is TGFB1; the disease is hepatocellular carcinoma.