HDAC1 and hepatocellular carcinoma: Downregulated (Peveling-Oberhag et al., 2014; Xie et al., 2014; Yu F. et al., 2015) MiR-34a induces apoptosis of HCC and decreases its proliferation by targeting the expression of HDAC1. It acts as a 3′UTR to regulate its expression on HCC cells (Peveling-Oberhag et al., 2014)