Downregulated (Su et al., 2009) miR-215 showed significant upregulation in HCC serum, and thus functions as a biomarker for early diagnosis in HCC patients miR-215 is significantly correlated with the important genes in Wnt/β-catenin pathway including. β-catenin, APC, and c-myc (Ashmawy et al., 2017). Here, APC is linked to hepatocellular carcinoma.