MiR-148a is among the five epigenetically downregulated miRNA by methylation and since DNMT1 and DNMT3B are considered to be two of its targets and responsible for its methylation, miR-148a together with DNMT1 and DNMT3B constitute a positive feedback mechanism which in the case of HCC leads to miR-148a downregulation (Duursma et al., 2008; Pan et al., 2010). Here, DNMT3B is linked to hepatocellular carcinoma.