Upregulated (Huang et al., 2009) The miR-17-92 cluster is the first oncogenic miRNAs identified in human (El-Badawy et al., 2017). This cluster targets thrombospondin-1 (TSP1), proangiogenic targets, and connective tissue growth factor (CTGF) to increase the potential of tumor angiogenesis (Sung et al., 2013). The gene discussed is CCN2; the disease is neoplasm.