Upregulated (Wang et al., 2008) Regulates carcinogenesis (Takahashi et al., 2014). MiR-183 suppress apoptosis in HCC cells through targeting Programmed cell death 4 (PDCD4). PDCD4 mediates its proapototic function in human HCC by being involved in the TGF-β1-induced apoptotic pathway (Li et al., 2010). This evidence concerns the gene TGFB1 and hepatocellular carcinoma.