BMI1 and hepatocellular carcinoma: Downregulated (Huang et al., 2009) Involved in enhancing proliferation and carcinogenesis (Caruso et al., 2012) miR-200b suppressed the expression of BMI1 and ZEB1, moreover ZEB1 promotes CD13, CD24, and EPCAM resulting in the upregulation of CD13 and CD24 so, the miR-200-ZEB1 circuit regulates stemness in HCC and differentiates between HCC contains CD13+/CD24+ CSCs from EpCAM + CSCs (Tsai et al., 2017)