MAPK8 and Alzheimer disease: The c-Jun N-terminal kinase (JNK) pathway is a known critical regulator of neuronal death in many diseases such as Alzheimer’s disease (AD) (Ando et al., 2011; Wang et al., 2013), Parkinson’s disease (PD) (Huang et al., 2016; Spigolon et al., 2018) and glaucoma (Welsbie et al., 2013; Mammone et al., 2018), and is considered a potential target for neuroprotective therapy (Wang et al., 2012; Kim et al., 2016).