DNER and acute myeloid leukemia: Several clinical trials testing BET inhibitors are currently ongoing; the small molecule RO6870810/TEN-010 (a more stable derivate of JQ1) has been tested in a recently completed phase I trial for the treatment of refractory AML and MDS (NCT02308761), and a phase II trial testing the BET inhibitor CPI-0610 in combination with ruxolitinib is open for patients with myelofibrosis (NCT02158858).