CDH2 and neoplasm: With regard to tumor metastasis, TCIRG1 was reported to modulate the EMT regulatory proteins, such as E-cadherin, N-cadherin, Fibronectin, Vimentin, Snail and Slug, and regulate tumor invasion and metastasis in MDA-MB-231, B16-F10, and SNU475 cells (Hinton et al., 2009; Yotsumoto et al., 2013; Yang et al., 2018; Zhou et al., 2018).