Although not being part of the typical disease features, pericarditis has been described in the setting of multiple autoinflammatory conditions, including Hyperimmunoglobulinemia D with periodic fever syndrome (HIDS) (60), NOD2-associated autoinflammatory syndrome (61), and chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) (62). This evidence concerns the gene NOD2 and autoinflammatory syndrome.