Genetic hijacking of ERG and GATA1 activities represents a common theme among pediatric AMKL as constitutive trisomy 21 (a.k.a. Down's syndrome) AMKL disease progression is characterized by independent genetic alterations also impacting ERG (carried by chromosome 21) and GATA1 (Figure 3) (26, 27). The gene discussed is ERG; the disease is Down syndrome.