However, activation in long-term hematopoietic stem cells (LT-HSC) resulted in some animals in a particularly aggressive AML characterized by high expression levels of the transcription factors MECOM (MDS1 and EVI1 complex locus, a.k.a. EVI1) and ERG, which also characterize human AML with poor outcome (68). The gene discussed is RUNX1; the disease is acute myeloid leukemia.