In contrast to adult AML, mutations in regulators of DNA methylation and histone modification including Ten-Eleven Translocation2 (TET2), IDH1 or IDH2, Enhancer of Zeste Homolog 2 (EZH2), DNMT3A, and Additional Sex Combs like-1 (ASXL1) are much less prevalent, affecting only about 1–2% of pediatric patients (51). The gene discussed is IDH2; the disease is acute myeloid leukemia.