Previously, we have evaluated the ability of more than 40 RD proteins, mainly from RD1-3 and RD10-14 segments of M.tb H37Rv, to induce specific IFN-γ production by ELISPOT and have found that Rv1768 (PE_PGRS31) evoked the higher TB-specific IFN-γ, response ranked only second to Rv2645 (Luo et al., 2015). This evidence concerns the gene IFNG and tuberculosis.