With the absence of MVA85A efficacy against TB in infants previously vaccinated with BCG (phase 2b trial, NCT00953927) (Tameris et al., 2013) and the moderate performance of current TB diagnostic methods in children, like the established clinical QFT and T-SPOT assays, which contain MTB-specific antigens, ESAT6 and CFP10, encoded by the RD1 region (Luo et al., 2019). Here, PDE6B is linked to tuberculosis.