Recently, it has been described that Zika virus (ZIKV) infection blocks SG assembly (Amorim et al., 2017; Basu et al., 2017; Hou et al., 2017; Bonenfant et al., 2019) despite a strongly induced translational shutoff and activation of both PKR- and UPR-induced phosphorylation of eIF2α, suggesting that ZIKV impairs SG assembly downstream of eIF2α phosphorylation (Hou et al., 2017). This evidence concerns the gene EIF2A and Zika virus infectious disease.