Also in mouse model of chronic asthma, administration of TRPV1 antagonist capsazepine (CPZ) or TRPV1 siRNA attenuated airway inflammation, hypersensitiveness, as well as reduced levels of cytokines IL-4, IL-5, IL-13 (type 2 T helper cytokines), and Thymic Stromal Lymphopoietin (TSLP), IL-25, IL-33 (epithelial cell-derived cytokines) (30). This evidence concerns the gene TRPV1 and chronic asthma.