Studying the expression of miR-375 and its target gene SMAD family member 7 (SMAD7) polymorphisms (rs4939827) in colorectal cancer (CRC) patients found that there was a significant association between miR-375 and the susceptibility to CRC, and that miR-375 and rs4939827 SNP in SMAD7 could be considered as a potential biomarker for early diagnosis of CRC (18). Here, SMAD7 is linked to colorectal carcinoma.