Older age [odd ratio (OR): 310.19; p = 0.007]; Child-Pugh classification B or C (OR: 15.24; p = 0.047); higher AFP (OR: 128.49; p = 0.008); higher PIVKA-II (OR: 118.54; p = 0.027); and larger PTV (OR: 51.31; p = 0.026) were significant factors for newly developed sarcopenia after RT. The gene discussed is AFP; the disease is sarcopenia.