The existence of conflicting reports about PD-L1 and−2 prognostic value can be generally attributed to technical disparities (e.g., variations in staining protocols across individual laboratories and use of different primary antibody clones to identify PD-Ls in tumor tissue), as well as different clinical features of the analyzed samples (site and size of cancer, treatments, follow-up time, etc.). The gene discussed is CD274; the disease is cancer.