Pembrolizumab administration has been also investigated in a single cohort trial enrolling 98 patients with recurrent or metastatic cervical cancer, expressing PD-L1 with a positive ratio of the number of all PD-L1–expressing cells (tumor cells, lymphocytes, macrophages) to the number of all tumor cells, or a Combined Positive Score (CPS) ≥1. The gene discussed is CD274; the disease is neoplasm.