Moreover, a KEGG pathway analysis revealed associations of these proteins with 197 signaling pathways, of which the following were identified as the top 10: the metabolic pathway, focal adhesion, cell-cell connections, proteoglycan in carcinoma, cell extracellular matrix receptor interaction, complement and coagulation cascades, the PI3K-Akt signal pathway, dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and amoebiasis. The gene discussed is AKT1; the disease is amebiasis.