For instance, while 320 nM ruxolitinib was reported to eliminate the enhancing effect of G-CSF in HT93A leukemia cells (37), a ruxolitinib concentration of at least 50 μM was required to induce a significant drop in cell proliferation in hepatocellular carcinoma cell lines HuH7, SNU182, and SNU423 (38). The gene discussed is CSF3; the disease is hepatocellular carcinoma.