It is approved by FDA for breast cancer treatment, and has been used in clinical settings for different types of cancer (27, 28); and (c) Erlotinib (ERL; selective ErbB1/EGFR inhibitor): Small molecules that target Erb family of receptors collectively (pan-ErbB inhibitors) and selectively, have been studied in clinical settings. This evidence concerns the gene EGFR and breast carcinoma.