As several clinical parameters, such as gender, smoking status, and histopathological type, have been reported to be informative for EGFR mutational status in NSCLC (49), we combined several clinical parameters (including age, gender, smoking status, clinical stage, and lesion location) with these developed signatures to create integrated models in order to evaluate how these clinical factors affect the performance of these radiomics signatures. Here, EGFR is linked to non-small cell lung carcinoma.