To explore the biological functions and signaling pathways of the risk signature, GO and pathway analysis were performed on these target genes, many terms associated with glioma progression were obtained, such as regulation of cell proliferation, cell migration, apoptotic process, response to hypoxia, angiogenesis, focal adhesion, the PI3K-AKT signaling pathway, cell cycle, and HIF-1 signaling pathway. The gene discussed is AKT1; the disease is glioma.