Bellance et al. suggested that mitochondrial biogenesis was diminished or damaged in lung cancer because they found diminished levels of mRNA for PGC-1α, reduced expression of PGC-1α and TFAM proteins, as well as, lower quantities of total mitochondrial area/cell area in lung cancer biopsies with respect to non-cancer tissue (21). Here, PPARGC1A is linked to lung carcinoma.