HIF1A and familial pancreatic carcinoma: Additionally, in human pancreatic cancer cell lines, hypoxia has been shown to drive EMT in an NFκB dependent manner through the stability of hypoxia-inducible factor 1 alpha (HIF-1α) and subsequent activation of RelA (p. 65) (60–63), a subunit of the NFκB family of transcription factors (64, 65).