To introduce sPD-L1 and sPD-L2 as biomarkers for disease status and outcome, we evaluated levels of sPD-L1 and sPD-L2 in sera of 83 primary EOC patients retrospectively and related these results with the presence of CTCs, clinical characteristics including FIGO-stage, tumor grade, lymph node infiltration, presence of metastases, residual tumor burden and platinum resistance as well as PFS and OS. Here, SPDL1 is linked to neoplasm.